Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 9, 1463 - 1464 (2003)
doi:10.1038/nm1203-1463
Prion disease: bridging the spleen-nerve gap
Neil A Mabbott1 & Moira E Bruce1
- Neil A. Mabbott and Moira E. Bruce are at the Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh EH9 3JF, UK. e-mail: neil.mabbott@bbsrc.ac.uk or e-mail: moira.bruce@bbsrc.ac.uk
Abstract
Infection of tissues outside the nervous system occurs in a number of prion diseases, but sporadic Creutzfeldt-Jakob disease in humans has not been considered one of them. A clinical study of Swiss patients with sporadic disease reconsiders this assumption, and a second study examines the spread of infection between follicular dendritic cells and nerves.
Two recent studies from Adriano Aguzzi's laboratory provide new insights into the biology of transmissible spongiform encephalopathies (TSEs, or prion diseases). In the 30 October issue of Nature, Prinz et al.1 show that manipulations of the architecture of lymphoid tissues can influence the progression of TSEs.
To read this story in full you will need to login or make a payment (see right).
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE REVIEWS NEWS AND VIEWS RESEARCH |
