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Nature Medicine 9, 1461 - 1462 (2003)
doi:10.1038/nm1203-1461

Marrow to muscle, fission versus fusion

Michael A Rudnicki1

  1. Michael A. Rudnicki is at the Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada. e-mail: mrudnicki@ohri.ca

Bone marrow cells can reconstitute muscle, but which cells contribute to the process, and how do they do it? Two studies trace the journey of a single hematopoietic stem cell into muscle tissue (pages 1520–1527 and 1528–1532).

In the last five years, several reports have suggested that hematopoietic stem cells (HSCs) could contribute to muscle regeneration after bone marrow transplantation. The potential of this approach has engendered much excitement as a possible therapy for the treatment of neuromuscular degenerative disorders such as Duchenne muscular dystrophy.

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REFERENCE
Regeneration of Muscle
Nature Encyclopaedia of Life Sciences

REVIEWS
Looking back to the embryo: defining transcriptional networks in adult myogenesis
Nature Reviews Genetics Review (01 Jul 2003)

RESEARCH
Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates
Nature Medicine Article (01 Dec 2003)
Contribution of hematopoietic stem cells to skeletal muscle
Nature Medicine Letters (01 Dec 2003)
Cell Invasion Is Affected by Differential Expression of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Muscle Satellite Cells from Normal and Dystrophic Patients
Laboratory Investigation Article (01 Jan 2001)
 See all 5 matches for Research