Nature Medicine9, 1528 - 1532 (2003)
Published online: 16 November 2003; | doi:10.1038/nm959
Contribution of hematopoietic stem cells to skeletal muscle
Stéphane Y Corbel1, Adrienne Lee1, Lin Yi1, Jeffrey Duenas1, Timothy R Brazelton2, Helen M Blau2
& Fabio M V Rossi1
1
The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.
2
Baxter Laboratory in Genetic Pharmacology, Departments of Molecular Pharmacology and Microbiology and Immunology, Stanford University School of Medicine, CCSR4215, Stanford, California 94305, USA.
Correspondence should be addressed to Fabio M V Rossi Fabio@brc.ubc.ca
Cells from adult bone marrow participate in the regeneration of damaged skeletal myofibers. However, the relationship of these cells with the various hematopoietic and nonhematopoietic cell types found in bone marrow is still unclear. Here we show that the progeny of a single cell can both reconstitute the hematopoietic system and contribute to muscle regeneration. Integration of bone marrow cells into myofibers occurs spontaneously at low frequency and increases with muscle damage. Thus, classically defined single hematopoietic stem cells can give rise to both blood and muscle.
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