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Nature Medicine 9, 1352 (2003)
doi:10.1038/nm1103-1352
A TUG on glucose transport
Alan R Saltiel1
- Alan R. Saltiel is at the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA. e-mail: saltiel@med.umich.edu
Abstract
Glucose transport into the cell is a delicate process that is highly responsive to insulin. A newly identified protein that may tether to the glucose transporter helps keep glucose traffic running smoothly in human cells.
One of the first defects in the development of type 2 diabetes is the failure of insulin to stimulate glucose uptake into fat and muscle cells1, 2. The facilitative transporter GLUT4 mediates this process.
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