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Nature Medicine  9, 1370 - 1376 (2003)
Published online: 12 October 2003; | doi:10.1038/nm948

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

Alexandra Aicher, Christopher Heeschen, Christiane Mildner-Rihm, Carmen Urbich, Christian Ihling, Katja Technau-Ihling, Andreas M Zeiher & Stefanie Dimmeler
 
Figure 1 thumbnailFigure 1.
In vivo recruitment of hematopoietic stem cells and EPCs into the circulation.

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Rescue of impaired angiogenic phenotype in eNOS-deficient mice by intravenous (i.v.) injection of wild-type cells.

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Incorporation of infused CellTracker-labeled BMCs into the vascular structures of limb muscles of Nos3-/- mice on day 7 after induction of ischemia.

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Bone marrow transplantation of wild-type cells does not rescue the impaired angiogenic phenotype of Nos3-/- mice.

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In vitro characterization of hematopoietic stem cells from Nos3-/- and wild-type (WT) bone marrow.

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Molecules involved in stem and progenitor cell mobilization.

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