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Journal home Advance online publication Current issue Archive Press releases Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Nature Immunology Nature Cell Biology Nature Genetics news@nature.com Nature Conferences Dissect Medicine NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Perspective Nature Medicine  9, 1359 - 1362 (2003) Published online: 31 October 2003; | doi:10.1038/nm941 Gradual adaptation of HIV to human host populations: good or bad news? Christian Brander & Bruce D Walker Christian Brander and Bruce D. Walker are at the Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA, and the Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA. B.D.W. is also at the Howard Hughes Medical Institute. Correspondence should be addressed to Christian Brander cbrander@partners.orgThe continuous evolution and adaptation of HIV to its host has produced extensive global viral diversity. Understanding the kinetics and directions of this continuing adaptation and its impact on viral fitness, immunogenicity and pathogenicity will be crucial to the successful design of effective HIV vaccines. Here we discuss some potential scenarios of viral and host coevolution. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REVIEWS The causes and consequences of HIV evolution Nature Reviews Genetics Review (01 Jan 2004) NEWS AND VIEWS HIV escape: there and back again Nature Medicine News and Views (01 Mar 2004)  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Open Innovation Challenges Optimizing Sub-cellular Localization Tags Deadline: Jan 31 2010 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... Direct Molecular Detection of Proteins and Nucleic Acids Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id... More Challenges Powered by: nature jobs One Postdoctoral Position at Centre for Research in Agricultural Genomics The Centre for Research Agricultural Genomics Consorcio CSIC-IRTA-UAB Barcelona Spain Multiple Academic Positions in Psychology University of Toronto-Scarsborough Scarborough Ontario, Canada More science jobs Post a job for free Figures & Tables Export citation Search buyers guide:   ADVERTISEMENT

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