Robert Walczak and Peter Tontonoz are at the Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California 90095-1662, USA. ptontonoz@mednet.ucla.edu
One approach to developing antiobesity drugs is to shift the energy balance in the body in favor of burning fat. A transcriptional coactivator is now assigned this task.
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is reduced in the adipose tissue of morbidly obese subjects
