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Letter
Nature Medicine 9, 1318-1322 (1 October 2003) | doi:10.1038/nm895;
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
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Abstract
Glucocorticoids, acting through the glucocorticoid receptor, potently modulate immune function and are a mainstay of therapy for treatment of inflammatory conditions, autoimmune diseases, leukemias and lymphomas. Moreover, removal of systemic glucocorticoids, by adrenalectomy in animal models or adrenal insufficiency in humans, has shown that endogenous glucocorticoid production is required for regulation of physiologic immune responses.
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