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News and Views
Nature Medicine 9, 1260 - 1262 (2003)
doi:10.1038/nm1003-1260
There is an Erratum (November 2003) associated with this News and Views.
-receptor polymorphisms: heart failure's crystal ball
David A Kass1
- David A. Kass is at Halsted 500, Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, Maryland 21287, USA. e-mail: dkass@jhmi.edu
Abstract
A polymorphism present in about half the general population can predispose to heart failure as well as enhance responsiveness to 
-blockers. The mechanism for this is now being revealed (pages 1300–1305).
Heart failure is typified by a reduced capacity of the heart to provide adequate blood flow and pressure for the body's demands. Drugs that interact with -adrenergic signaling, such as -blockers and angiotensin-pathway inhibitors, are widely prescribed for patients with heart failure and those with diseases such as hypertension that often lead to heart failure.
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