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Nature Medicine 9, 1259 - 1260 (2003)
doi:10.1038/nm1003-1259
The new immunosuppression: just kill the T cell
Herman Waldmann1
- Herman Waldmann is at the Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK. e-mail: herman.waldmann@pathology.oxford.ac.uk
Abstract
Antibodies to the CD40 ligand have modulated the immune system in animal experiments and in human clinical trials. Assumptions about how these antibodies work are now reexamined (pages 1275–1280).
It is now 50 years since Medawar demonstrated that immunological tolerance could be acquired in newborn mice1. Since then, the challenge to immunologists has been to achieve therapeutic tolerance in the areas of transplantation, autoimmune disease and allergy.
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