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Nature Medicine 9, 1257 - 1259 (2003)
doi:10.1038/nm1003-1257
Exposing the roots of hair cell regeneration in the ear
Matthew W Kelley1
- Matthew W. Kelley is in the Section on Developmental Neuroscience, National Institute on Deafness and other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland 20850, USA. e-mail: kelleymt@nidcd.nih.gov
Abstract
Robust regeneration of hair cells, which mediate hearing and balance in the ear, occurs in most vertebrates, with the exception of mammals. Now, the identification of stem cells in the mouse inner ear that can give rise to hair cells raises the prospect of inducing regeneration in mammals as well (pages 1293–1299).
As many as 25 million Americans experience some form of progressive hearing loss, and that number will increase as the population continues to live longer. By far, the primary cause of age-related hearing loss is the loss of mechanosensory hair cells located within a specialized sensory epithelium that extends along the coiled cochlea of the inner ear.
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