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Nature Medicine  9, 1300 - 1305 (2003)
Published online: 14 September 2003; | doi:10.1038/nm930

bold beta1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

Jeanne Mialet Perez, Deborah A Rathz, Natalia N Petrashevskaya, Harvey S Hahn, Lynne E Wagoner, Arnold Schwartz, Gerald W Dorn II & Stephen B Liggett
 
Figure 1 thumbnailFigure 1.
Functional consequences of polymorphic beta1-AR expression in transgenic mouse hearts.

Full FigureFull Figure and legend (41K)		 Figure 2 thumbnailFigure 2.
Phenotypic switching of Arg389 and Gly389 beta1-AR signaling in mouse and human ventricles.

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Figure 3 thumbnailFigure 3.
Cardiac gene expression profiles from polymorphic beta1-AR transgenic mice.

Full FigureFull Figure and legend (16K)		 Figure 4 thumbnailFigure 4.
Allele-specific features of Arg389 and Gly389 beta1-AR in transgenic mice and human heart failure.

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Figure 5 thumbnailFigure 5.
Altered expression of calcium-cycling and beta-AR signaling proteins in 6-month-old Arg389 hearts.

Full FigureFull Figure and legend (30K)		 Table 1 thumbnailTable 1.
Echocardiographic indices of 9-month-old mice

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