Herman Waldmann is at the Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK. herman.waldmann@pathology.oxford.ac.uk
Antibodies to the CD40 ligand have modulated the immune system in animal experiments and in human clinical trials. Assumptions about how these antibodies work are now reexamined (pages 1275−1280).
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