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Nature Medicine  9, 1257 - 1259 (2003)
doi:10.1038/nm1003-1257

Exposing the roots of hair cell regeneration in the ear

Matthew W Kelley

Matthew W. Kelley is in the Section on Developmental Neuroscience, National Institute on Deafness and other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland 20850, USA. kelleymt@nidcd.nih.gov

Robust regeneration of hair cells, which mediate hearing and balance in the ear, occurs in most vertebrates, with the exception of mammals. Now, the identification of stem cells in the mouse inner ear that can give rise to hair cells raises the prospect of inducing regeneration in mammals as well (pages 1293−1299).

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REFERENCE
Hair Cells
Nature Encyclopaedia of Life Sciences

RESEARCH
Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears
Nature Neuroscience Article (01 Jun 2000)
Pluripotent stem cells from the adult mouse inner ear
Nature Medicine Article (01 Oct 2003)
Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1
Nature Genetics Letters (01 Apr 2000)

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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