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| Recent technological advances have fueled biomedical progress more than in any other time in history. We celebrate this fact by featuring a collection of articles on the technological trends that will shape the future of molecular medicine. |
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Dear Reader, p1
doi:10.1038/nm0103-1
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(258K)
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| Letters to Editor | Top |
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Elevated  -secretase expression and enzymatic activity detected in sporadic Alzheimer disease pp3 - 4
Li-Bang Yang, Kristina Lindholm, Riqiang Yan, Martin Citron, Weiming Xia, Xiao-Li Yang, Thomas Beach, Lucia Sue, Philip Wong, Donald Price, Rena Li
& Yong Shen
doi:10.1038/nm0103-3
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(112K)
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Measuring T-cell−mediated cytotoxicity using antibody to activated caspase 3 pp4 - 5
Keith R. Jerome, Derek D. Sloan
& Martine Aubert
doi:10.1038/nm0103-4
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(70K)
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| News | Top |
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Biotech meets NIH to discuss poor disease markets p7
Alan Dove
doi:10.1038/nm0103-7a
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(89K)
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Test panels no better than internal review pp7 - 8
Chris Dickey
doi:10.1038/nm0103-7b
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(138K)
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NCI to focus on clinical trial speed p8
Kristine Novak
doi:10.1038/nm0103-8
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(94K)
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Microarray to be used as routine clinical screen p9
Charlotte M. Schubert
doi:10.1038/nm0103-9a
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(159K)
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Drug costs threaten patent protection p9
Marlene Cimons
doi:10.1038/nm0103-9b
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(159K)
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Thomas Starzl p10
Karen Birmingham
doi:10.1038/nm0103-10
Abstract | Full text | PDF
(69K)
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| Book Reviews | Top |
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The Deadly Truth: A History of Disease in America p11
Reviewed by: Alfred W. Crosby
doi:10.1038/nm0103-11a
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(109K)
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The Genomic Revolution: Unveiling the Unity of Life pp11 - 12
Reviewed by: Amalia M. Issa
doi:10.1038/nm0103-11b
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(176K)
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| News and Views | Top |
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Immunotherapy for AIDS virus infections: Cautious optimism for cell-based vaccine pp13 - 14
Nina Bhardwaj
& Bruce D. Walker
doi:10.1038/nm0103-13
Abstract | Full text | PDF
(425K)
See also: Article by Lu et al. |
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Unmet expectations: The brain minds pp15 - 16
William A. Carlezon Jr.
& Roy A. Wise
doi:10.1038/nm0103-15
Abstract | Full text | PDF
(436K)
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Predicting the future of breast cancer pp16 - 18
Åke Borg, Mårten Fernö
& Carsten Peterson
doi:10.1038/nm0103-16
Abstract | Full text | PDF
(272K)
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Myelin management p18
Charlotte Schubert
doi:10.1038/nm0103-18
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(134K)
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Sensing heart stress pp19 - 20
Liza Barki-Harrington
& Howard A. Rockman
doi:10.1038/nm0103-19
Abstract | Full text | PDF
(114K)
See also: Article by Brancaccio et al. |
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Setting the cytokine trap for autoimmunity pp20 - 22
Charles A. Dinarello
doi:10.1038/nm0103-20
Abstract | Full text | PDF
(148K)
See also: Article by Economides et al. |
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In vivo imaging reveals estrogen receptor's hidden personality pp22 - 23
Geoffrey L. Greene
doi:10.1038/nm0103-22
Abstract | Full text | PDF
(208K)
See also: Article by Ciana et al. |
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The nucleolus: at the stem of immortality pp24 - 25
Rosa Bernardi
& Pier Paolo Pandolfi
doi:10.1038/nm0103-24
Abstract | Full text | PDF
(243K)
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Research News p26
Charlotte Schubert, Ushma Savla
& Suzanne Hingley-Wilson
doi:10.1038/nm0103-26
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(87K)
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| Articles | Top |
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Therapeutic dendritic-cell vaccine for simian AIDS pp27 - 32
Wei Lu, Xiaoxian Wu, Yaozeng Lu, Weizhong Guo
& Jean-Marie Andrieu
Published online: 23 December 2002 | doi:10.1038/nm806
Abstract | Full text | PDF
(615K)
See also: News and Views by Bhardwaj & Walker |
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Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways pp33 - 39
Wolfgang W. Leitner, Leroy N. Hwang, Michael J. deVeer, Aimin Zhou, Robert H. Silverman, Bryan R.G. Williams, Thomas W. Dubensky, Han Ying
& Nicholas P. Restifo
Published online: 23 December 2002 | doi:10.1038/nm813
Abstract | Full text | PDF
(582K)
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Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease pp40 - 46
Kamran Ghoreschi, Peter Thomas, Susanne Breit, Martin Dugas, Reinhard Mailhammer, Willem van Eden, Ruurd van der Zee, Tilo Biedermann, Jörg Prinz, Matthias Mack, Ulrich Mrowietz, Enno Christophers, Detlef Schlöndorff, Gerd Plewig, Christian A. Sander
& Martin Röcken
Published online: 02 December 2002 | doi:10.1038/nm804
Abstract | Full text | PDF
(619K)
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Cytokine traps: multi-component, high-affinity blockers of cytokine action pp47 - 52
Aris N. Economides, Laura Rocco Carpenter, John S. Rudge, Vivien Wong, Ellen M. Koehler-Stec, Christopher Hartnett, Erica A. Pyles, Xiaobing Xu, Thomas J. Daly, Michael R. Young, James P. Fandl, Frank Lee, Scott Carver, Jennifer McNay, Kevin Bailey, Swayampakula Ramakanth, Renta Hutabarat, Tammy T. Huang, Czeslaw Radziejewski, George D. Yancopoulos
& Neil Stahl
Published online: 16 December 2002 | doi:10.1038/nm811
Abstract | Full text | PDF
(140K)
See also: News and Views by Dinarello |
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Human and porcine early kidney precursors as a new source for transplantation pp53 - 60
Benjamin Dekel, Tatyana Burakova, Fabian D. Arditti, Shlomit Reich-Zeliger, Oren Milstein, Sarit Aviel-Ronen, Gideon Rechavi, Nir Friedman, Naftali Kaminski, Justen H. Passwell
& Yair Reisner
Published online: 23 December 2002 | doi:10.1038/nm812
Abstract | Full text | PDF
(1,647K)
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Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E pp61 - 67
Yuqing Huo, Andreas Schober, S. Bradley Forlow, David F. Smith, Matthew Craig Hyman, Steffen Jung, Dan R. Littman, Christian Weber
& Klaus Ley
Published online: 16 December 2002 | doi:10.1038/nm810
Abstract | Full text | PDF
(982K)
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Melusin, a muscle-specific integrin
1−interacting protein, is required to prevent cardiac failure in response to chronic pressure overload pp68 - 75
Mara Brancaccio, Luigi Fratta, Antonella Notte, Emilio Hirsch, Roberta Poulet, Simona Guazzone, Marika De Acetis, Carmine Vecchione, Gennaro Marino, Fiorella Altruda, Lorenzo Silengo, Guido Tarone
& Giuseppe Lembo
Published online: 23 December 2002 | doi:10.1038/nm805
Abstract | Full text | PDF
(621K)
See also: News and Views by Barki-Harrington & Rockman |
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Modulation of anxiety through blockade of anandamide hydrolysis pp76 - 81
Satish Kathuria, Silvana Gaetani, Darren Fegley, Fernando Valiño, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Giovanna La Rana, Antonio Calignano, Arcangela Giustino, Maria Tattoli, Maura Palmery, Vincenzo Cuomo
& Daniele Piomelli
Published online: 02 December 2002 | doi:10.1038/nm803
Abstract | Full text | PDF
(137K)
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In vivo imaging of transcriptionally active estrogen receptors pp82 - 86
Paolo Ciana, Michele Raviscioni, Paola Mussi, Elisabetta Vegeto, Ivo Que, Malcolm G. Parker, Clemens Lowik
& Adriana Maggi
Published online: 16 December 2002 | doi:10.1038/nm809
Abstract | Full text | PDF
(448K)
See also: News and Views by Greene |
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Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations pp87 - 92
Alexander G. Maier, Manoj T. Duraisingh, John C. Reeder, Sheral S. Patel, James W. Kazura, Peter A. Zimmerman
& Alan F. Cowman
Published online: 09 December 2002 | doi:10.1038/nm807
Abstract | Full text | PDF
(276K)
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Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity pp93 - 96
Olivier Silvie, Eric Rubinstein, Jean-François Franetich, Michel Prenant, Elodie Belnoue, Laurent Rénia, Laurent Hannoun, Wijnand Eling, Shoshana Levy, Claude Boucheix
& Dominique Mazier
Published online: 16 December 2002 | doi:10.1038/nm808
Abstract | Full text | PDF
(287K)
| Supplementary Information |
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| Foreword | Top |
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Technology Trends
Technology: pushing the boundaries of scientific discovery p97
Diane Gershon
doi:10.1038/nm0103-97
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(125K)
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| Commentaries | Top |
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Technology Trends
Can needle-free administration of vaccines become the norm in global immunization? pp99 - 103
Myron M. Levine
doi:10.1038/nm0103-99
Abstract | Full text | PDF
(109K)
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Technology Trends
Cell encapsulation: Promise and progress pp104 - 107
Gorka Orive, Rosa María Hernández, Alicia R. Gascón, Riccardo Calafiore, Thomas M.S. Chang, Paul De Vos, Gonzalo Hortelano, David Hunkeler, Igor Lacík, A.M. James Shapiro
& José Luis Pedraz
doi:10.1038/nm0103-104
Abstract | Full text | PDF
(151K)
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| Historical Perspective | Top |
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Technology Trends
The total artificial heart pp108 - 111
Denton A. Cooley
doi:10.1038/nm0103-108
Abstract | Full text | PDF
(323K)
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| Perspectives | Top |
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Technology Trends
Beyond six colors: A new era in flow cytometry pp112 - 117
Stephen C. De Rosa, Jason M. Brenchley
& Mario Roederer
Abstract | Full text | PDF
(639K)
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Technology Trends
Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries pp118 - 122
Clemencia Pinilla, Jon R. Appel, Eva Borràs
& Richard A. Houghten
doi:10.1038/nm0103-118
Abstract | Full text | PDF
(261K)
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| Reviews | Top |
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Technology Trends
Shedding light onto live molecular targets pp123 - 128
Ralph Weissleder
& Vasilis Ntziachristos
doi:10.1038/nm0103-123
Abstract | Full text | PDF
(480K)
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Technology Trends
Engineered antibodies pp129 - 134
Peter J. Hudson
& Christelle Souriau
doi:10.1038/nm0103-129
Abstract | Full text | PDF
(146K)
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Technology Trends
Ligand-directed targeting of genes to the site of disease pp135 - 139
Thomas J. Wickham
doi:10.1038/nm0103-135
Abstract | Full text | PDF
(1,185K)
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Technology Trends
Trends in microarray analysis pp140 - 145
Robin L. Stears, Todd Martinsky
& Mark Schena
doi:10.1038/nm0103-140
Abstract | Full text | PDF
(199K)
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| Errata | Top |
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Predicting the unpredictable: Transmission of drug-resistant HIV p146
S.M. Blower, A.N. Aschenbach, H.B. Gershengorn
& J.O. Kahn
doi:10.1038/nm0103-146a
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(90K)
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Stabilization of atherosclerotic plaques: New mechanisms and clinical targets p146
P. Libby
& M. Aikawa
doi:10.1038/nm0103-146b
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(90K)
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| Corrigenda | Top |
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Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis p146
R. Sharp, J.A. Recio, C. Jhappan, T. Otsuka, S. Liu, Y. Yu, W. Liu, M. Anver, F. Navid, L.J. Helman, R.A. DePinho
& G. Merlino
doi:10.1038/nm0103-146c
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(90K)
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Migration through host cells activates Plasmodium sporozoites for infection p146
M.M. Mota, J.C.R. Hafalla
& A. Rodriguez
doi:10.1038/nm0103-146d
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(90K)
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