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Nature Medicine 9, 19 - 20 (2003)
doi:10.1038/nm0103-19
Sensing heart stress
Liza Barki-Harrington1 & Howard A. Rockman1
- Department of Medicine, Cell Biology, and Genetics Duke University Medical Center Durham, North Carolina, USA e-mail: h.rockman@duke.edu
Abstract
Heart failure and pathological overgrowth of the heart often occur hand in hand. New data on a biomechanical sensor challenge the viewpoint that cardiac hypertrophy causes heart failure (pages 68–75).
The main function of the heart is to provide adequate delivery of oxygen to meet the metabolic demands of the body under conditions of normal and increased workload. Although the performance of the heart is well maintained over a wide range of physiological stressors, increased biomechanical stress from either exercise or disease can drive morphological changes in the heart muscle, known as cardiac hypertrophy.
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