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Nature Medicine 9, 13 - 14 (2003)
doi:10.1038/nm0103-13
Immunotherapy for AIDS virus infections: Cautious optimism for cell-based vaccine
Nina Bhardwaj1 & Bruce D. Walker2
- The New York University and the Rockefeller University New York, New York e-mail: bhardwn@rockefeller.edu
- Partners AIDS Research Center Massachusetts General Hospital, and Division of AIDS Harvard Medical School Boston, Massachusetts, USA e-mail: bwalker@partners.org
Abstract
A vaccine that is able to work as a treatment for HIV-infected patients has been an elusive goal. Now experiments on macaques suggest that injections of modified dendritic cells might boost immunity to hold back disease progression (pages 27–32).
Highly active antiretroviral therapy (HAART) limits HIV-1 replication and retards disease progression, but drug toxicities and emergence of drug-resistant viruses are challenges for long-term control in infected persons. Alternative treatment strategies are clearly needed.
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