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Volume 8 Issue 8, August 2002

The efficacy and low toxicity of the angiogenic factor placental growth factor (PIGF) and its receptor VEGFR1 may make them preferable to VEGF and its primary receptor VEGFR2 as stimulators of angiogenesis and hematopoiesis. In one of two studies of PIGF's action in the current issue, Hattori et al. (page 841) demonstrate that PIGF enhances hematopoiesis in mice following irradiation-induced bone-marrow suppression. Luttun et al. (page 831) report that delivery of PIGF improved revascularization of heart and limbs in ischemic mice, whereas an antibody against VEGFR1 reduced atherosclerosis, tumor growth and arthritic joint destruction. The cover image illustrates a cross-section of an arthritic joint, with chondrocytes embedded in a red safranin O-stained matrix of proteoglycans. Magnification, x63

Volume 8 Issue 8

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  • The neurotransmitter dopamine underlies most addictive processes—but its faint response to ethanol has puzzled researchers. New research suggests that ethanol interacts synergistically with adenosine and dopamine signaling to amplify the effect of drinking.

    • R. Adron Harris
    • Richard A. Morrisett
    News & Views

  • Murine antibodies that block cell-surface antigens have been engineered (humanized) to successfully elicit human immune-effector mechanisms. Now, a fully human antibody produced entirely in vitro kills tumor cells directly through signal transduction and shows promise against lymphoma in animal studies (pages 801–807).

    • Dan L. Longo
    News & Views

  • A newly discovered interplay between two human genes controlling the immune response to HIV has implications for antiretroviral drug therapy and the development of preventive vaccines.

    • Nelson L. Michael
    News & Views

  • There are currently no effective means to treat acute spinal cord injury, except for glucocorticoids, which produce moderate benefits at best. A new study suggests erythropoietin, now recognized as a potent neuroprotective cytokine, as a potential treatment for spinal cord injury.

    • Steven A. Goldman
    • Maiken Nedergaard
    News & Views

  • Evasion of the immune system is an all too common feature of cancer. A new study suggests one evasion mechanism: induction of T-cell apoptosis through B7-H1, a molecule expressed on the surface of many tumor cells (pages 793–800).

    • Gordon J. Freeman
    • Arlene H. Sharpe
    • Vijay K. Kuchroo
    News & Views

  • Before leaving the body, cholesterol is converted to bile acids. Two studies implicate the nuclear receptor SHP as a major player in bile-acid production—but not the only one.

    • Kristina Schoonjans
    • Johan Auwerx
    News & Views
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