Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 8, 789 - 791 (2002)
doi:10.1038/nm0802-789
A sharper image of SHP
Kristina Schoonjans1 & Johan Auwerx1
- Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, Parc d'Innovation, Illkirch, France e-mail: auwerx@igbmc.u-strasbg.fr
Abstract
Before leaving the body, cholesterol is converted to bile acids. Two studies implicate the nuclear receptor SHP as a major player in bile-acid production—but not the only one.
Maintaining a balance of cholesterol in the body involves the coordinate regulation of cholesterol biosynthesis, cholesterol uptake from the plasma and cholesterol catabolism in the liver. The conversion of cholesterol to bile acids represents a major pathway for cholesterol elimination from the body, a process that has been thought to receive input from the small heterodimer partner (SHP).
To read this story in full you will need to login or make a payment (see right).
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated NEWS AND VIEWS RESEARCH |
is an essential regulator of bile acid and plasma cholesterol metabolism