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Journal home Advance online publication Current issue Archive Press releases Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Nature Immunology Nature Cell Biology Nature Genetics news@nature.com Nature Conferences Dissect Medicine NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Medicine  8, 787 - 789 (2002) doi:10.1038/nm0802-787 Protect the killer: CTLs need defenses against the tumor Gordon J. Freeman1, Arlene H. Sharpe2 & Vijay K. Kuchroo3 1  Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School Boston, Massachusetts, USA 2  Department of Pathology, Harvard Medical School Boston, Massachusetts, USA 3  Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School Boston, Massachusetts, USA kuchroo@rics.bwh.harvard.edu Evasion of the immune system is an all too common feature of cancer. A new study suggests one evasion mechanism: induction of T-cell apoptosis through B7-H1, a molecule expressed on the surface of many tumor cells (pages 793−800). MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE Immunoregulation Nature Encyclopaedia of Life Sciences  See all 8 matches for Reference REVIEWS THE B7–CD28 SUPERFAMILY Nature Reviews Immunology Review (01 Feb 2002)  See all 24 matches for Reviews NEWS AND VIEWS More negative feedback? Nature Immunology News and Views (01 Jul 2003) T-cell stimulation: an abundance of B7s Nature Medicine News and Views (01 Dec 1999)  See all 7 matches for News And Views RESEARCH Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion Nature Medicine Article (01 Aug 2002) The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses Nature Immunology Article (01 Sep 2003)  See all 39 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Novel Approaches to Protecting Maize from Insect Damage Deadline: Jan 31 2010 Reward: $20,000 USD The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re... Optimizing Sub-cellular Localization Tags Deadline: Jan 31 2010 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... More Challenges Powered by: nature jobs Chief Scientific Manager - Medicinal Chemistry Syngene International Bangalore, Karnataka 560099 India Postdoctoral Positions Johns Hopkins University Baltimore, Maryland, USA More science jobs Post a job for free Figures & Tables See also: Article by Dong et al. Export citation Search buyers guide:   ADVERTISEMENT

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