RNA interference meets HIV-1: Will silence be golden?
Roger J. Pomerantz
The Dorrance Hamilton Laboratories Center for Human Virology, Division of Infectious Diseases Department of Medicine, Jefferson Medical College Thomas Jefferson University Philadelphia, Pennsylvania, USA roger.j.pomerantz@mail.tju.edu
RNA interference first gained notoriety in invertebrates and plants as a means to target genes for deactivation. Now, in vitro studies suggest that in human cells, this process can inhibit HIV-1 replication and potentially act as a novel and potent anti-retroviral therapy (pages 683−688).
