Weill Medical College of Cornell University Department of Pharmacology, New York, New York, USA ssgross@med.cornell.edu
Nitric oxide (NO) is a potent vasodilator that is produced in endothelial cells and has been assumed to act exclusively at its site of synthesis. New evidence suggests that red blood cells distribute NO bioactivity, matching blood flow to tissue oxygen demands and endowing NO with features of a hormone (pages 711−717).
