There is an Erratum (September 2002) associated with this Article.
Acute graft-versus-host disease does not require alloantigen expression on host epithelium
Takanori Teshima1, Rainer Ordemann1, Pavan Reddy1, Svetlana Gagin1, Chen Liu2, Kenneth R. Cooke1
& James L. M. Ferrara1
1
Departments of Internal Medicine and Pediatrics, University of Michigan Cancer Center, Ann Arbor, Michigan, USA
2
Department of Pathology, University of Florida College of Medicine, Gainesville, Florida, USA
Correspondence should be addressed to James L. M. Ferrara ferrara@umich.edu
Alloantigen expression on host antigen-presenting cells (APCs) is essential to initiate graft-versus-host disease (GvHD); therefore, alloantigen expression on host target epithelium is also thought to be essential for tissue damage. We tested this hypothesis in mouse models of GvHD using bone-marrow chimeras in which either major histocompatibility complex class I or class II alloantigen was expressed only on APCs. We found that acute GvHD does not require alloantigen expression on host target epithelium and that neutralization of tumor necrosis factor- and interleukin-1 prevents acute GvHD. These results pertain particularly to CD4-mediated GvHD but also apply, at least in part, to CD8-mediated GvHD. These results challenge current paradigms about the antigen specificity of GvHD effector mechanisms and confirm the central roles of both host APCs and inflammatory cytokines in acute GvHD.
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and interleukin-1 prevents acute GvHD. These results pertain particularly to CD4-mediated GvHD but also apply, at least in part, to CD8-mediated GvHD. These results challenge current paradigms about the antigen specificity of GvHD effector mechanisms and confirm the central roles of both host APCs and inflammatory cytokines in acute GvHD.
