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News and Views
Nature Medicine  8, 555 - 556 (2002)
doi:10.1038/nm0602-555

FANCD2: A branch-point in DNA damage response?

Markus Grompe

Department of Molecular and Medical Genetics Oregon Health Science University Portland, Oregon, USA grompem@ohsu.edu

The Fanconi anemia D2 protein is vital for cellular resistance to DNA cross-linking. Now, FANCD2 is shown to also be involved in a second, independent function, the arrest of DNA synthesis after ionizing radiation.

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The DNA crosslink-induced S-phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathways
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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