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News and Views
Nature Medicine  8, 450 - 451 (2002)
doi:10.1038/nm0502-450

CREB family transcription factors inhibit neuronal suicide

Ted M. Dawson1, 2 & David D. Ginty2, 3

1  Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
tdawson@jhmi.edu

2  Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3  Department of Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
dginty@hjmi.edu

Neurodenerative disorders such as Huntington disease lead to neuronal cell death in discrete regions of brain. A new study implicates the CREB transcription factor family as critical mediators that prevent such neuronal death.

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REFERENCE
Huntington Disease
Nature Encyclopaedia of Life Sciences

REVIEWS
Experimental therapeutics in transgenic mouse models of Huntington's disease
Nature Reviews Neuroscience Review (01 May 2004)

NEWS AND VIEWS
Polyglutamine and CBP: Fatal attraction?
Nature Medicine News and Views (01 May 2001)
Huntington's disease: Exploiting expression
Nature News and Views (18 Oct 2001)
 See all 4 matches for News And Views

RESEARCH
Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration
Cell Death and Differentiation Original Article (21 Feb 2002)
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription
Nature Genetics Article (01 Sep 2000)
 See all 5 matches for Research

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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