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Nature Medicine 8, 331 - 333 (2002)
doi:10.1038/nm0402-331
Juvenile autoimmune diabetes: A pathogenic role for maternal antibodies?
Matthias von Herrath1 & Jean-Francois Bach2
- La Jolla Institute for Allergy and Immunology San Diego, California, USA
e-mail: matthias@liai.org - Necker Hopital, Paris, France
Abstract
Type 1 diabetes has long been thought of as a T cell–mediated disease. Now, a new study in mice makes a strong case that maternal autoantibodies can play an essential role in the initiation of diabetes. (pages 399–402)
Autoimmunity is characterized by the immune-mediated destruction of organs or cells. Depending on the nature of disease, cellular (T cell–mediated) and humoral (antibody-mediated) mechanisms can come into play.
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