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News and Views
Nature Medicine  8, 338 - 340 (2002)
doi:10.1038/nm0402-338


There is a Corrigendum (June 2002) associated with this News and Views.

Not just research tools—proteasome inhibitors offer therapeutic promise

Alfred L. Goldberg1 & Kenneth Rock2

1  Department of Cell Biology Harvard Medical School Boston, Massachusetts, USA

2  Department of Pathology University of Massachusetts Medical Center Worcester, Massachusetts, USA
alfred_goldberg@hms.harvard.edu

Proteasome inhibitors have served as critical tools to investigate protein degradation in eukaryotic cells. Now, these inhibitors are proving effective in the treatment of cancer and inflammatory disorders, most recently in animal models of psoriasis.

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REFERENCE
Ubiquitin Pathway
Nature Encyclopaedia of Life Sciences

RESEARCH
Proteasome inhibitor induced gene expression profiles reveal overexpression of transcriptional regulators ATF3, GADD153 and MAD1
Oncogene Original Article (12 Jun 2000)
Imaging 26S proteasome activity and inhibition in living mice
Nature Medicine null (01 Jul 2003)

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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