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Volume 8 Issue 2, February 2002

Editorial

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Letters to the Editor

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News

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Commentary

  • A few, high profile disasters in clinical trials in recent years have thrust the area of human subject research into the regulatory spotlight. The US has been quickest to react to public concern by introducing systems to tighten-up oversight mechanisms. The UK is now examining its clinical policies and here the authors question the best way forrward.

    • Andrew J.T. George
    • Rodney Gale
    • David Korn
    Commentary
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Book Review

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News & Views

  • The demonstration that transplanted embryonic stem cells differentiate into functional dopamine neurons and provide stable functional recovery in a rodent model of Parkinson disease moves the field a step closer to clinical applications of embryonic stem cells.

    • Rosemary A. Fricker-Gates
    • Stephen B. Dunnett
    News & Views
  • Transplant recipients require chronic administration of drugs that suppress their immune system to prevent rejection of foreign tissues. The finding in rats that grafting embryonic stem-like cells to a transplant recipient can induce tolerance to transplants has important clinical implications. (pages 171–178)

    • Scott H. Adler
    • Steven J. Bensinger
    • Laurence A. Turka
    News & Views
  • The α isoform of the IκB protein kinase has been identified as the missing link in a signaling pathway that controls mammary epithelial proliferation via the cell-cycle regulator cyclin D1. This new player may provide a promising target for inhibiting cyclin D1 expression, which is elevated in 50% of breast malignancies.

    • Sibylle Tonko-Geymayer
    • Wolfgang Doppler
    News & Views
  • Migraine sufferers experience pounding headaches, which sometimes are preceded by a visual aura. Now Bolay et al. show that cortical-spreading depression, the cause of the aura, activates trigeminal afferents, which act to cause inflammation of the pain-sensitive meninges, generating the headache. (pages 136–142)

    • Costantino Iadecola
    News & Views
  • Increased levels of circulating triglyceride and free fatty acids are common features of diabetic dyslipidemia. Positional cloning has led to the identification of a liver-derived protein, angiopoietin-like protein 3, that is largely responsible for diabetic dyslipidemia in an animal model of type 2 diabetes mellitus.

    • Luciano Rossetti
    • Ira J. Goldberg
    News & Views
  • Mucosal cells are the principal portal of HIV-1 entry. A new study in this issue shows that upon contact with a X4 and R5 virus subtype mixture present in the inoculum, mucosal epithelial cells are themselves resistant to virus infection. Rather, they select the R5 virus subtype for transport across the cell, bringing the virus in contact with mucosal CD4+ T lymphocytes, which starts the chain of infection. (pages 150–156)

    • Morgane Bomsel
    • Violaine David
    News & Views
  • A new study identifies the chemokine CCL27 and its receptor CCR10 as important homing molecules for T-cell migration to the skin. Moreover, they find that CCL27 inhibition suppresses some skin-inflammatory responses, suggesting that therapies targeting CCL10 could be used to treat several human skin disorders. (pages 157–165)

    • Charles R. Mackay
    News & Views
    • Kristine Novak
    • Alex Urioste
    News & Views
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Article

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On the Market

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