Mucosal gatekeepers: Selecting HIV viruses for early infection
Morgane Bomsel
& Violaine David
Entrée muqueuse du VIH et immunité muqueuse Departement de Biologie Cellulaire Institut Cochin de Génétique Moléculaire Paris, France
bomsel@cochin.inserm.fr
Mucosal cells are the principal portal of HIV-1 entry. A new study in this issue shows that upon contact with a X4 and R5 virus subtype mixture present in the inoculum, mucosal epithelial cells are themselves resistant to virus infection. Rather, they select the R5 virus subtype for transport across the cell, bringing the virus in contact with mucosal CD4+ T lymphocytes, which starts the chain of infection. (pages 150−156)
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