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Article
Nature Medicine 8, 1414 - 1420 (2002)
Published online: 4 November 2002 | doi:10.1038/nm1202-792
cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
Simona Frigerio1, Tobias Junt2, Bao Lu3, Craig Gerard3, Urs Zumsteg1, Georg A. Holländer1,4 & Luca Piali1,4
Abstract
T cell–mediated loss of insulin-secreting 
cells in the islets of Langerhans is the hallmark of type 1 diabetes. The molecular basis for the directed migration of autoreactive T cells leading to insulitis is presently unknown. Here we demonstrate that in response to inflammation, cells secrete the chemokines CXC ligand 10 and CXC ligand 9, which specifically attract T-effector cells via the CXC chemokine receptor 3. In mice deficient for this receptor, the onset of type 1 diabetes is substantially delayed. Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes.
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