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Nature Medicine 8, 1360 - 1361 (2002)
doi:10.1038/nm1202-1360
Crowd control in the crypt
Catherine Booth1, Gerard Brady1 & Christopher S. Potten1
- EpiStem Ltd. Manchester, UK e-mail: c.booth@epistem.co.uk
Abstract
Cancer can ensue when cells do not know who they are or where they are. In the intestine, a single regulator seems to take care of both of these issues of identity.
Colorectal cancer, the third most common cancer in the United States, can be thought of as a disease of the long-lived stem-cell populations. In the intestine, stem cells reside near the bottom of flask-like invaginations, called crypts.
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