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Nature Medicine 8, 1352 - 1353 (2002)
doi:10.1038/nm1202-1352
Vessel maneuvers: Vaccine targets tumor vasculature
Michael S. O'Reilly1
- Departments of Radiation Oncology and Cancer Biology University of Texas M.D. Anderson Cancer Center Houston, Texas, USA e-mail: moreilly@mdanderson.org
Abstract
A new oral vaccine targets a receptor in newly forming blood cells and thwarts angiogenesis in mouse models of cancer (pages 1369–1375).
Since its inception over three decades ago, the field of angiogenesis has made significant progress and has led to an improved understanding of physiological and pathophysiological conditions1. However, a number of obstacles remain before the anti-tumor effects of anti-angiogenic therapy in mice2 can be translated to clinical practice.
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