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Nature Medicine  8, 1421 - 1426 (2002)
Published online: 25 November 2002; | doi:10.1038/nm1202-801

The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs

Alon Chen, Yonatan Ganor, Shai Rahimipour, Nurit Ben-Aroya, Yitzhak Koch & Mia Levite
 
Figure 1 thumbnailFigure 1.
GnRH-I and GnRH-II genes and peptides are expressed in human T cells and can activate T cells to produce the laminin receptor.

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 Figure 2 thumbnailFigure 2.
GnRH-II and GnRH-I induce adhesion of human T cells to laminin and increase their in vitro migration toward the chemoattractant SDF-1alpha.

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Figure 3 thumbnailFigure 3.
EL-4 T-lymphoma cells express the 67 kD LR, and GnRH stimulation increases its expression and enhances entry of the T-lymphoma in vivo into the bone marrow and spleen of recipient mice.

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