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Nature Medicine  8, 1243 - 1248 (2002)
doi:10.1038/nm1102-1243

The liver X receptor gene team: Potential new players in atherosclerosis

Joyce J. Repa1 & David J. Mangelsdorf2

1  Departments of Physiology and Internal Medicine, Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA

2  Howard Hughes Medical Institute and the Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Correspondence should be addressed to David J. Mangelsdorf davo.mango@utsouthwestern.edu
Liver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has implicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.

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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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