The liver X receptor gene team: Potential new players in atherosclerosis
Joyce J. Repa1
& David J. Mangelsdorf2
1
Departments of Physiology and Internal Medicine, Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
2
Howard Hughes Medical Institute and the Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Liver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has implicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.
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