Volume 8 Issue 10, October 2002
Several articles in this issue explore the mechanisms by which cancer subverts cell-cycle controls, leading to unchecked proliferation. In one of these reports (on page 1105), Lazarov et al. find that in primary epidermal cells, upregulation of the cyclin-dependent kinase CDK4 is required in conjunction with expression of an activated Ras oncogene to induce malignant transformation resembling human squamous-cell carcinoma. The cover image depicts a human invasive epidermal tumor induced by Ras and CDK4, and stained for involucrin (orange), Type VII collagen (green) and DNA (blue). Magnification, x20.
Editorial
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