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Commentary
Nature Medicine 8, 1059 - 1062 (2002)
doi:10.1038/nm770
The machinery and principles of vesicle transport in the cell
James E. Rothman1
- Cellular Biophysics and Biochemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
A defining feature of the eukaryotic cell is its compartmentalized cytoplasm of functionally specialized membrane-bound organelles. This internal organization creates a network of complementary reaction vessels that enable biochemical processes to occur without interference, as well as a matrix of distinct surfaces on which needed signaling modules can coalesce on demand.
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