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Nature Medicine 8, 1086 - 1087 (2002)
doi:10.1038/nm1002-1086
EBV framed in Burkitt lymphoma
Samuel H. Speck1
- Division of Microbiology and Immunology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia, USA e-mail: sspeck@rmy.emory.edu
Abstract
Epstein–Barr virus (EBV) is associated with the development of several types of cancers. Now, gene-expression profiling suggests that EBV-driven B-cell proliferation may actually drive progression to Burkitt lymphoma (pages 1098–1104).
Epstein–Barr virus (EBV) was discovered through its tight association with the endemic form of Burkitt lymphoma (BL), the most common childhood cancer in equatorial Africa. EBV is also associated with the development of several other human cancers, including nasopharyngeal carcinoma, 30–50% of Hodgkin lymphomas and approximately 50% of lymphomas arising in immunosuppressed patients1.
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