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Nature Medicine 8, 1084 - 1085 (2002)
doi:10.1038/nm1002-1084
Oxidized lipid protects against sepsis
Niels C. Riedemann1 & Peter A. Ward1
- Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA e-mail: pward@umich.edu
Abstract
Treatment with an oxidized phospholipid markedly reduces tissue damage in a mouse model of sepsis. But will the approach be feasible in humans?
Sepsis in animals and in humans is a systemic inflammatory response to live bacteria and/or bacterial products. This response is expressed as a variety of different clinical presentations, such as fever, increased blood leukocyte counts (especially neutrophils), increased cardiac output and other evidence of physiological distress.
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