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Nature Medicine 8, 1080 - 1082 (2002)
doi:10.1038/nm1002-1080
Inflammation intersection: gp130 balances gut irritation and stomach cancer
Timothy C. Wang1 & James R. Goldenring2
- Gastroenterology Division and Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts, USA e-mail: timothy.wang@umassmed.edu
- Vanderbilt-Ingram Cancer Center and Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Abstract
The stomach and the intestine respond differently to inflammation. Work on the cytokine receptor gp130 helps explain why cancer develops in the stomach and inflammatory bowel disease hits the intestine (pages 1089–1097).
The seemingly unrelated diseases gastric cancer and inflammatory bowel disease (IBD) share in common an origin in chronic inflammation. Often triggered by the bacterium Helicobacter pylori, inflammation in the stomach appears to nudge relatively undifferentiated epithelial cells into a program of unregulated growth.
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