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Nature Medicine 8, 1076 - 1078 (2002)
doi:10.1038/nm1002-1076
Breast cancer banishes p27 from nucleus
Stacy W. Blain1 & Joan Massagué2
- State University of New York Downstate Medical Center, Brooklyn, New York, USA
- Memorial Sloan–Kettering Cancer Center and Howard Hughes Medical Institute, New York, New York, USA e-mail: j-massague@ski.mskcc.org
Abstract
The cell-cycle inhibitor p27 is phosphorylated by the Akt kinase in breast cancer, according to three new studies. This phosphorylation keeps p27 in the cytoplasm and correlates with cancer aggressiveness (pages 1136–1144, 1145–1152 and 1153–1160.)
Most genes known to control the cell cycle are mutated in cancer, some of them quite frequently. These include famous genes such as K-ras and p53.
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