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Nature Medicine  8, 1122 - 1128 (2002)
Published online: 23 September 2002; | doi:10.1038/nm780

A futile metabolic cycle activated in adipocytes by antidiabetic agents

Hong-Ping Guan, Yong Li, Mette Valentin Jensen, Christopher B. Newgard, Claire M. Steppan & Mitchell A. Lazar
 
Figure 1 thumbnailFigure 1.
TZDs increase GyK expression in adipocytes.

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Ciglitazone induces GyK expression in ob/ob mice, lean mice, rats and human primary adipocytes.

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Figure 3 thumbnailFigure 3.
Rosiglitazone robustly increases glycerol incorporation into TG in adipocytes.

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Rosiglitazone treatment markedly diminishes fatty-acid release from adipocytes, as does GyK overexpression.

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Figure 5 thumbnailFigure 5.
Model for the effects of TZD treatment on physiology of lipid storage and mobilization in adipocytes.

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