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Nature Medicine  8, 1089 - 1097 (2002)
Published online: 9 September 2002; | doi:10.1038/nm763

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

Niall C. Tebbutt, Andrew S. Giraud, Melissa Inglese, Brendan Jenkins, Paul Waring, Fiona J. Clay, Sina Malki, Barbara M. Alderman, Dianne Grail, Frédéric Hollande, Joan K. Heath & Matthias Ernst
 
Figure 1 thumbnailFigure 1.
Altered intracellular signaling in mice with targeted gp130 mutations.

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Histological analysis of gp130757F mice.

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Figure 3 thumbnailFigure 3.
Increased susceptibility to DSS-mediated intestinal injury in 12−16-wk-old mice.

Full FigureFull Figure and legend (113K)		 Figure 4 thumbnailFigure 4.
Tissue-specific regulation of trefoil peptide level in gp130 mutant mice.

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Figure 5 thumbnailFigure 5.
Reciprocal responsiveness of genes encoding pS2/TFF1 and ITF/TFF3 to the SHP2-Ras-ERK and STAT pathways activated by gp130-signaling domain mutants.

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Schematic of the consequences of impairing the reciprocal negative regulation between the SHP2-Ras-ERK and STAT1/3 pathways.

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