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Volume 8 Issue 1, January 2002

Diffuse large B-cell lymphomas are the most common lymphoid malignancy in adults and curable in less than 50% of patients. Currently, clinical factors are used in prognosis of the disease to identify patients who are unlikely to be cured with standard chemotherapy. On page 68 of this issue, Shipp et al. use gene-expression profiling and supervised machine learning to more accurately predict the outcome of disease and give molecular insight into its pathogenesis. The cover image depicts a stylized representation of a diffuse large B-cell lymphoma (H&E stain, x640).

Volume 8 Issue 1

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  • Antagonists of the αvβ3 and αvβ5 integrins inhibit angiogenesis in cancer, arthritis and ischemic retinopathy. However, a surprising new report suggests that knockout mice lacking β3 and/or β5 integrins show enhanced, rather than reduced angiogenesis. (pages 27–34)

    • Peter Carmeliet
    News & Views

  • Conditional deletion of the Pten tumor suppressor gene in the nervous system demonstrates that Pten is an important regulator of proliferation in neural stem cells and soma size in neurons.

    • Sean J. Morrison
    News & Views

  • Defects in the mechanisms responsible for maintaining the heart's rhythmic contractions can be fatal. The finding that a defect in a potassium-channel accessory protein can predispose mice to cardiac arrhythmia provides insights into the molecular basis of this group of diseases.

    • Michael C. Sanguinetti
    News & Views

  • The finding that cleavage and shedding of the membrane-bound heparin-binding epidermal growth factor by metalloproteases contribute to the hypertrophic process offers new insights for the treatment of cardiac hypertrophy and progression to heart failure. (pages 35–40)

    • James K. Liao
    News & Views

  • Tumor-specific, 'signature' mutations of p53 have been identified in several cancers. The molecular basis of these tissue-specific selections has been poorly understood. A recent report sheds light on this issue by identifying the molecular basis of one such signature mutation found in adrenal cortical carcinomas.

    • Pierre Hainaut
    News & Views

  • Attention deficit/hyperactivity disorder is often treated with stimulant drugs such as methylphenidate. However, this treatment remains controversial, as some studies have suggested that sensitization to these drugs of abuse predispose towards adult drug addiction. A new study, using juvenile rats, now shows that chronic treatment with methylphenidate during adolescence actually reduces drug-seeking behavior during adulthood.

    • Trevor W. Robbins
    News & Views
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