Access

Letters to Editor

Nature Medicine 8, 3 - 4 (2002)
doi:10.1038/nm0102-3

Aging alters the apoptotic response to genotoxic stress

Yousin Suh1,3, Kang-Ae Lee1,3, Woo-Ho Kim2,3, Bok-Ghee Han4, Jan Vijg5 & Sang Chul Park1,3

  1. Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine Seoul, Korea
  2. Department of Pathology, Seoul National University College of Medicine Seoul, Korea
  3. Cancer Research Institute Seoul National University College of Medicine Seoul, Korea
  4. Central Genome Center, National Institute of Health, Seoul, Korea
  5. Sam and Ann Barshop Center for Longevity and Aging Studies University of Texas Health Science Center San Antonio, Texas,zz USA
    e-mail: suhys@plaza1.snu.ac.kr or e-mail: scpark@plaza.snu.ac.kr

Increased apoptosis is known to contribute to age-related pathologies in post-mitotic tissues such as brain1. Although it has been postulated2, 3, 4 experimental evidence for a decline in apoptotic response during aging, which may lead to loss of phenotypic fidelity and a subsequent accumulation of errors, is lacking.