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Nature Medicine 8, 20 - 21 (2002)
doi:10.1038/nm0102-20
Shedding growth factors in cardiac hypertrophy
James K. Liao1
- Cardiovascular Division, Department of Medicine Brigham & Women's Hospital and Harvard Medical School Cambridge, Massachusetts, USA
e-mail: jliao@rics.bwh.harvard.edu
Abstract
The finding that cleavage and shedding of the membrane-bound heparin-binding epidermal growth factor by metalloproteases contribute to the hypertrophic process offers new insights for the treatment of cardiac hypertrophy and progression to heart failure. (pages 35–40)
Cardiac hypertrophy is an adaptive physiological response to increases in blood pressure that preserves myocardial wall stress, chamber size and contractile function. Despite these initial advantages, cardiac hypertrophy is also an independent risk factor for cardiovascular disease and, if left untreated, it frequently progresses to heart failure1.
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