Department of Neurology, Medical School University of Newcastle upon Tyne Newcastle upon Tyne, UK
r.n.lightowlers@ncl.ac.uk
Unequivocal evidence for the dynamic nature of mammalian mitochondria has been hard to find. However, the successful development of a transgenic mouse model carrying pathogenic mtDNA as reported here will cause us to take a fresh look at these dynamic organelles. (pages 934−940)