Nature Medicine
7, 781 - 787 (2001)
doi:10.1038/89901
Replication-selective virotherapy for cancer: Biological principles, risk management and future directionsDavid Kirn1, 4, Robert L. Martuza2
& James Zwiebel31
Viral and Genetic Therapy Programme, Imperial College School of Medicine and the Imperial Cancer Research Fund, Hammersmith Hospital, London, UK
2
Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
3
Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA
4
d.kirn@icrf.icnet.uk
In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underlying biological principles and current status of the field, outlines approaches for improving clinical effectiveness and discusses the unique safety and regulatory issues surrounding viral therapies.
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