Life after death: Controlling autoreactive CD8+ T-cell responses
Thomas J. Braciale
University of Virginia Health Science Center Carter Immunology Center Departments of Pathology and Microbiology Charlottesville, Virginia, USA
tjb2r@virginia.edu
The uptake of apoptotic CD40L+ cells by immature dendritic cells leads to dendritic-cell activation. This mechanism might account for the generation of autoreactive CD8+ T cells in HIV infection and indicates a general mechanism for the regulation of autoimmune T-cell responses during infection. (pages 807−813)
