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Nature Medicine 7, 656 - 657 (2001)
doi:10.1038/89019
A protective player in the vascular response to injury
Stephen M. Schwartz1
- University of Washington Department of Pathology Seattle, Washington, USA
e-mail: steves@u.washington.edu
Abstract
Heme oxygenase-1, an enzyme expressed during injury, reduces vasoconstriction and inhibits formation of free radicals. Someday it might be used as a local therapeutic agent at sites of vascular injury (Pages 693–698).
Vascular diseases such as atherosclerosis, graft failure and restenosis are all associated with reactive oxygen-species–induced injury. Reactive oxygen species have been implicated in vasospasm, the loss of endothelial-dependent vasodilatation, and a variety of toxic effects attributed to oxidized lipids.
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