Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Defective DNA polymerase-δ proofreading causes cancer susceptibility in mice

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Reduced survival and increased tumor incidence in Pold1D400A/D400A mice.

References

  1. Hanahan, D. & Weinberg, R.A. The hallmarks of cancer. Cell 100, 57–70 (2000).

    CAS  PubMed  Google Scholar 

  2. Loeb, L.A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51, 3075–3079 (1991).

    CAS  PubMed  Google Scholar 

  3. Buermeyer, A.B., Deschenes, S.M., Baker, S.M. & Liskay, R.M. Mammalian DNA mismatch repair. Annu. Rev. Genet. 33, 533–564 (1999).

    Article  CAS  PubMed  Google Scholar 

  4. Morrison, A., Johnson, A.L., Johnston, L.H. & Sugino, A. Pathway correcting DNA replication errors in Saccharomyces cerevisiae. EMBO J. 12, 1467–1473 (1993).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Burgers, P.M. Eukaryotic DNA polymerases in DNA replication and DNA repair. Chromosoma 107, 218–227 (1998).

    Article  CAS  PubMed  Google Scholar 

  6. Derbyshire, V., Pinsonneault, J.K. & Joyce, C.M. Structure function analysis of 3′→5′ exonuclease of DNA polymerases. Methods Enzymol. 262, 363–385 (1995).

    Article  CAS  PubMed  Google Scholar 

  7. Simon, M., Giot, L. & Faye, G. The 3′ to 5′ exonuclease activity located in the DNA polymerase δ subunit of Saccharomyces cerevisiae is required for accurate replication. EMBO J. 10, 2163–2170 (1991).

    Article  Google Scholar 

  8. Perrino, F.W. & Loeb, L.A. Hydrolysis of 3′-terminal mispairs in vitro by the 3′→5′ exonuclease of DNA polymerase δ permits subsequent extension by DNA polymerase α. Biochemistry 29, 5226–5231 (1990).

    Article  CAS  PubMed  Google Scholar 

  9. Datta, A. et al. Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants. Mol. Cell 6, 593–603 (2000).

    Article  CAS  PubMed  Google Scholar 

  10. Li, G.M. The role of mismatch repair in DNA damage-induced apoptosis. Oncol. Res. 11, 393–400 (1999).

    CAS  PubMed  Google Scholar 

  11. Kunkel, T.A. & Bebenek, K. DNA replication fidelity. Annu. Rev. Biochem. 69, 497–529 (2000).

    Article  CAS  PubMed  Google Scholar 

  12. Flohr, T. et al. Detection of mutations in the DNA polymerase δ gene of human sporadic colorectal cancers and colon cancer cell lines. Int. J. Cancer 80, 919–929 (1999).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goldsby, R., Lawrence, N., Hays, L. et al. Defective DNA polymerase-δ proofreading causes cancer susceptibility in mice. Nat Med 7, 638–639 (2001). https://doi.org/10.1038/88963

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/88963

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing